![]() A synthetic oscillatory network of transcriptional regulators. Understanding systems-level properties: Timely stories from the study of clocks. Modeling the cell cycle: Why do certain circuits oscillate? Cell 144, 874–885 (2011). Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Building a cell cycle oscillator: Hysteresis and bistability in the activation of cdc2. A model based on receptor desensitization for cyclic amp signaling in dictyostelium cells. Biochemical Oscillations and Cellular Rhythms: The Molecular Bases of Periodic and Chaotic Behaviour (Cambridge Univ. Thermodynamics of statistical inference by cells. Chemical sensing by nonequilibrium cooperative receptors. The cost of sensitive response and accurate adaptation in networks with an incoherent type-1 feed-forward loop. The energy–speed–accuracy tradeoff in sensory adaptation. Lan, G., Sartori, P., Neumann, S., Sourjik, V. Physical limits on cellular sensing of spatial gradients. ![]() Physical limits to biochemical signaling. Lehninger Principles of Biochemistry (Macmillan, 2008).īialek, W. Chemical Biophysics: Quantitative Analysis of Cellular Systems (Cambridge Univ. Free Energy Transduction and Biochemical Cycle Kinetics (Academic, 1977). Muscle contraction and free energy transduction in biological systems. Experimental evidence in support of this general relationship and testable predictions are also presented.Įisenberg, E. Microscopically, we find that the oscillation is driven by multiple irreversible cycles that hydrolyse fuel molecules such as ATP the number of phase coherent periods is proportional to the free energy consumed per period. This relationship and its range of validity are shown analytically in a model of noisy oscillation. In all the systems studied, we find that the phase diffusion constant depends on the free-energy dissipation per period, following the same inverse relation parameterized by system-specific constants. Here, we study three different types of biochemical oscillation, representing three basic oscillation motifs shared by all known oscillatory systems. It remains poorly understood how biochemical circuits suppress these phase fluctuations and what is the incurred thermodynamic cost. However, in this noisy environment, oscillations can be highly inaccurate owing to phase fluctuations. Oscillations within the cell regulate the timing of many important life cycles.
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